On version 10.4, I found that I while Qspice launches, I was unable to install it with this staging version, and also once installed I could not launch other processes from QUX. The model creator would not open, and the simulator would not launch. I don’t know if this is an issue with my specific system. I have a sneaking suspicion it is related to the recent refactoring of how 32 bit and 64 bit executables (wow64) was implemented to avoid the need for separate 32 and 64 bit wine installs or something?
I tried to add the repos for the latest 10.7 staging version but there was conflicts with the fedora supplied packages and while I could open the wine tools wine itself didn’t appear to install, or the PATH was not set.
Bottles is intended to be installed as a flatpak for better containerization of programs and avoiding dependency hell like what I was experiencing so I reinstalled bottles from flathub as the devs intended and then installed the kron4ek staging 10.7 version of in Preferences -> Runners menu.
I had to use flatseal to modify the permissions of the Bottles app so it can access /home and then map /home to Z:\ volume within the Qspice bottle.
It works pretty well although I still have occasional stability and performance issues. At least it is usable unlike Kicad’s included ngspice sim. It would be 
amazing @Engelhardt would contribute his knowledge to improve it! 