Dw1000 custom board

I hate to say it but your layout looks terrible.

The bypassing capacitors are on long thing traces.
All of the power and grounds are long and thing rather than directly into planes.
Your impedance control on the antenna trace is non-existent, the 100 ohm differential pair are the same width as the 50 ohm trace to the antenna.

This is an RF chip, copying the schematic isn’t enough, you’ve got to get the layout correct. That takes a 4 layer board minimum.